The problem of impact loading of anisotropic aluminum targets by isotropic steel projectile is considered for loading velocities 200m/s, 300m/s and 600m/s. The influence of the effect of anisotropy elastic, plastic and strength characteristics of the target material on the change of a wave picture of a target stressed state is investigated. The problem is solved numerically by the method of finite elements in three-dimensional setting. The deformation of the steel isotropic projectile occurs according to model of Prandtl-Reuss of elasticplastic flow. The deformation of anisotropic material of target is calculated by means generalized Hooke’s law in the area of elastic deformation and by the flow theory – in the area of plastic deformation. As the criterion of destruction of anisotropic material of target it was used Misses – Hill condition of destruction. The influence of the effect of the reduced mechanical properties of a target from aluminum alloy 2024 (D16T) along its gage as compared to strength characteristics in the rolled plane is shown by numerical modeling of deformation process for given target.